The Quatro is very nice but WAY expensive and you'd get about the same performance with any CUDA enabled card, like a GTX980 for example. Bear in mind that different software works better or worse with some cards and even driver versions, so that definitely comes into play. I run Sony Vegas for my video work and it is picky as fuck about this kind of thing! Other things like Premiere or After Effects are a lot more forgiving (and to be fair, Vegas is being phased out in favour of Sony's new Catalyst suite, so they know it's got baked in issues not worth fixing. I'll be jumping ship when Catalyst is on par with the feature set of Vegas). As far as motherboard goes, really any solid brand made in the last year or so will do just fine. Load up your RAM though, and make it as fast as you can get it (that'll determine what board you get - some boards don't support really fast RAM). I doubt you'd need more than 32 gig of RAM. I'm running 24 just fine. CPU wise, you'll want an i7 because of the hyperthreading. For gaming, an i5 is actually better but video editing does a lot of parallel processing and benefits from the extra threads. Anything from the last year or so will be fine. I'd personally avoid the newest generation chips for a little while, until they're a bit more baked in. That's not to say you won't get a stable machine at all, but when a lot of the new chipsets are running new specs of USB3 and Thunderbolt, etc., there's always a potential for trouble if the drivers aren't mature enough yet, which will be exposed once you really slam them with demanding software, like video editing stuff. Do NOT skimp on a PSU! Aside from RAM being dodgy, this is the fastest way to make a system unstable as fuck. Get a Gold rated one, and you'd be looking at 1000w minimum so you can power the video card and the silly amount of power a good CPU eats these days. Nice quiet case fans are a must, and you'd want several hard drives. The price of SSDs have come down a fair bit now, and I'd go for a Samsung Evo 850 for the system drive. I'd have a dedicated video files drive since it's not sharing bandwidth with the system drive. With that, a SSD will give you great performance but even HD video will chew through space pretty fast, let alone 4K, so you really need to weigh up how you want to do stuff. If you're just doing HD, a good quality mechanical drive will go pretty well. 4K is a different story - you'd be looking at a RAID array to get the most out of that, or a couple of SSDs chained together for space. I'd also recommend a good backup / rendering drive too, which is fine to be mechanical rather than SSD since you'd need more space rather than speed for that. Now bear in mind that what I mentioned there will easily hit $5000 or more, so you'd need to prioritise. A last generation i7 will be fine, 24 - 32 gig of RAM will be more than enough (even 16 if you want to push it), a good PSU, you can get away with less than the 980 for the video card for most programs (I'm still running a 580 and it's doing just fine so anything more than that will work great, so long as it has a good amount of video RAM on board). A SSD for the boot drive is a great idea, and then you just need to decide how much to drop on the video files drive(s). As I said, if it's just HD, save money and get a speedy HDD rather than SSD or RAID array. Sorry for not going into specifics but every bit of software works a bit differently and tech is changing REALLY fast so you may find that any advice I give will already be out of date once you go looking. Hope that helps your friend out a bit!