I only just got into messing with reaper, but that is because it wasn't till version 3 that it was even usable on mac. Up till version 3 the mac version was the largest piece of shit I have ever used (and that includes ableton live). The DAWS I have used heavy are pro tools and cubase. DAWS I'm familiar with and can work with are Audition, Reaper, Logic, and Record (I got to beta test Record). I have to agree with Adam, out of the box I think Reaper is wacky as shit. lol It basically stems from seeing how things generally look in other sequencers and daws. Another poor GUI IMO is the Abelton live one, it just makes me go WTF? But Reaper has some other nice things such as the metering and input selection and I found setting up I/O to be easy. I really didn't like how Reaper is setup out of the gate. Tons of menus are not my idea of a solid easy workflow. I'm also so used to mouse tools that the constant smart tool idea turned me off pretty bad. It reminded me of Garageband and in my head from using Garageband it just reminded me of how unprofessional it is.