My main combo that i've been messing around with lately is the Cali Diamond plate (from my pod xt pro) with tube screamer. I have the cab sim off and i run that through the Catharsis S-preshigh impulse. Then some post processing should give you that tight tone with minimal amount of nasty fizz that u get from amp sims. I'm constantly experimenting with different amp head sims and post processing techniques. Ill be happy to share with you guys if i get a new tone worth sharing. So what amp/cab combo are u working with at the moment?