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the cleans need to come down for sure, the screams sound about the right level the majority of the time
 
Sounds good i really like the guitar tone what was the chain?? And what preamps are you using??? Compress the main clean vocals a little more and TUNE THEM... they need more tuning if they are already tuned...
 
shouts sound really thin and like he's standing in a small bathroom shouting into a guitar pickup. way too much distortion, you should use this on a effect channel if you havn't allready. It sounds like you used it on the insert and it's destroying the whole signal. In the breakdown part at the end you could copy the vocals and pitch them down to make them sound heavier. Just an idea I had while listening :)
 
they need more mids it sounds like, and you're going a little overkill on the JFAC reverse snare lead ins.